Phase 1 Clinical Trials

Phase 1 Clinical Trials

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While browsing through our list of open cancer clinical trials, you might notice that some are labeled with phases that graduate from Phase 0 to Phase 4. If you’re interested in participating in a Phase 1 trial but aren’t sure what the process might involve or what to expect, Regional Cancer Care Associates’ quick overview of this type of cancer clinical trial can help you make a more informed, confident decision.

What Are Clinical Trials?

Trials are categorized into phases based on the type of information gathered. For example, Phase 0 studies are typically just for exploratory research, while Phase 4 studies usually look at drugs that have already been approved by the U.S. Food and Drug Administration (FDA). Each study builds on the knowledge gained from previous studies.

Purpose of Phase 1 Studies

In a Phase 1 study, an investigational treatment is given to humans, often for the first time. Extensive research has already been done and the drug has been tested in the laboratory, but now it’s time to see how safe and effective the agent is for humans. The main goal is to determine the impact of a specified drug on the human body and how it interacts with that drug.

In general, Phase 1 studies help researchers figure out the best dosages to give to patients with cancer. In the process, they also help identify any potential side effects of a new drug, although at this phase rare side effects can be more difficult to detect. The results of Phase 1 studies can then be used to get a better understanding of the drug and how doctors can use it to help current and future cancer patients.

How Phase 1 Studies Are Conducted

Phase 1 cancer clinical trials often involve only a small group of people, and it’s common for them to have different types of cancer. Researchers start by administering extremely low doses to patients and then gradually introduce higher doses. There are no placebos (dummy pills) in Phase 1 trials, which means every participant receives the new drug.

Going into Phase 1 cancer clinical trials, some participants may feel apprehensive or fearful. But it’s important to know that these trials are safe and you’ll be closely monitored for side effects the whole time. Plus, the screening process helps verify whether you’d be a good candidate for the trial. If you have any questions, always reach out to your doctor.

Join a Phase 1 Clinical Trial Now

Interested in learning more about cancer clinical trials? If you would like to take part in a trial, RCCA offers a complete list of all available Phase 3 studies. To learn more, review our current list of all clinical trials, contact one of our 30 locations throughout New Jersey, Connecticut, and Maryland or call 201-518-3587 for additional details.

find a clinical trial

If you have any questions or are interested in participating in one of our Clinical Trials, please take note of the associated protocol number and contact our team at (201) 518-3587, or email us at email.

67 Clinical Trials
Phase 1 Clinical Trials Phase I Active
nct/study# NA / SET101

A Phase 1/1b, Open-Label Multi-Center Two Part Study Of Setd2 Inhibitor Ezm0414 In Subjects With Relapsed/Refractory Multiple Myeloma And Relapsed/Refractory Diffuse Large B Cell Lymphoma

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Phase 1 Clinical Trials Phase II Accepting Patients
nct/study# NCT03915951 / ARRAY-818-202

A Phase 2, Open-Label Study Of Encorafenib + Binimetinib In Patients With BRAFV600E-Mutant Non-Small Cell Lung Cancer

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Phase 1 Clinical Trials Phase I/II Accepting Patients
nct/study# NCT02744287 / BP-012

A Phase 1/2 Feasibility, Safety, And Activity Study Of PSCA-Specific Chimeric Antigen Receptor Engineered T Cells (BPX-601) In Subjects With Previously Treated Advanced Solid Tumors

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Phase 1 Clinical Trials Phase I Accepting Patients
nct/study# NCT04650451 / BPX603-201A

A Phase 1/2, Open-Label, Multicenter, Non-Randomized, Safety And Activity Study Of Her-Targeted Dual Switch Car-T Cells (Bpx-603) In Subjects With Previously Treated Advanced Her2-Positive Solid Tumors

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Phase 1 Clinical Trials Phase I/II Accepting Patients
nct/study# NCT02913313 / CA020-002

Phase 1/2a First-In-Human Study Of BMS-986207 Monoclonal Antibody Alone And In Combination With Nivolumab In Advanced Solid Tumors

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Phase 1 Clinical Trials Phase I/II Accepting Patients
nct/study# NCT03110107 / CA022-001

Phase 1/2a First-In-Human Study Of BMS-986218 Monoclonal Antibody Alone And In Combination With Nivolumab In Advanced Solid Tumors

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We are here for you

For more information or to schedule an appointment, call (844) 346-7222. You can also schedule an appointment by calling the RCCA location nearest you.

Regional Cancer Care Associates is one of fewer than 200 medical practices in the country selected to participate in the Oncology Care Model (OCM); a recent Medicare initiative aimed at improving care coordination and access to and quality of care for Medicare beneficiaries undergoing chemotherapy treatment.