[[{"@type":["BlogPosting"],"@id":"https:\/\/www.regionalcancercare.org\/news\/jtcc-presents-genomic-data-on-poor-risk-diffuse-large-b-cell-lymphoma-using-targeted-dna-and-rna\/#BlogPosting","@context":{"@vocab":"http:\/\/schema.org\/","kg":"http:\/\/g.co\/kg"},"url":["https:\/\/www.regionalcancercare.org\/news\/jtcc-presents-genomic-data-on-poor-risk-diffuse-large-b-cell-lymphoma-using-targeted-dna-and-rna\/","https:\/\/www.regionalcancercare.org\/news\/jtcc-presents-genomic-data-on-poor-risk-diffuse-large-b-cell-lymphoma-using-targeted-dna-and-rna\/"],"publisher":[{"@id":"https:\/\/www.regionalcancercare.org\/"}],"author":[{"@type":"Organization","@id":"https:\/\/www.regionalcancercare.org\/news\/jtcc-presents-genomic-data-on-poor-risk-diffuse-large-b-cell-lymphoma-using-targeted-dna-and-rna\/#BlogPosting_author_Organization","name":"Regional Cancer Care Associates"}],"inLanguage":"en-US","headline":"JTCC Presents Genomic Data on Poor Risk Diffuse Large B-Cell Lymphoma Using Targeted DNA and RNA\u2026","dateModified":"2021-11-11T14:47:02+00:00","datePublished":"2013-12-10T03:31:28+00:00","articleBody":"\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\tDecember 10, 2013\t\t\t\t\t\n\t\t\t\t\t\t\t\t\n\t\t\t\t\nDecember 09, 2013 03:30 PM Eastern Standard Time\nASH 2013\nHACKENSACK, N.J.\u2013(BUSINESS WIRE)\u2013Andre Goy, M.D., Chairman and Director, and Chief of Lymphoma, John Theurer Cancer Center and Chief Science Officer and Director of Research and Innovation of Regional Cancer Care Associates, presented new data providing further insight into the complexity of the genomic landscape in high-risk diffuse large B-cell lymphoma (DLBCL), the most common subtype of Non-Hodgkin Lymphoma (NHL) among adults. The oral abstract was presented today during Session 622 at 3:15 p.m. in the Ernest N. Morial Convention Center at the 2013 American Society of Hematology (ASH) Annual Meeting in New Orleans, LA.\n\u201cThese data demonstrate the potential clinical utility of FoundationOne Heme and represent an important step forward in advancing patient care and enabling precision medicine for patients with large B-cell lymphoma\u201d\nAmong lymphomas \u2013 the most frequent form of blood cancers \u2013 there are many subtypes with different manifestations. More than 50% of patients with diffuse large cell lymphoma are cured with a combination of monoclonal rituximab with CHOP (cyclophosphamide, Hydroxydaunorubicin (doxorubicin), Oncovin (vincristine) and prednisone). Unfortunately, patients can experience relapses or recurrences. Most occur early \u2013 within the first two years \u2013 and patients often experience very poor outcomes.\nHowever, thanks to the human genome project and progress in understanding cancer cell biology, researchers can now look inside the cells and see how they have been \u201crewired,\u201d as a result of genetic mutations.\nA number of studies at ASH report on the genetic differences among lymphoma patients, though they seem to have the \u201csame lymphoma under the microscope.\u201d\nTargeted DNA and RNA sequencing of 35 DLBCL primary tumors from very poor outcome DLBCL patients with a median OS of 8.4 months (range .3-44.5 months) identified 214 genomic alterations \u2013 an average of 6.1 per sample in 71 genes. There was a low overall failure rate (1\/36 samples for DNA, 2\/36 for RNA), deep unique coverage and simultaneous detection of multiple rearrangements (BCL2, BCL6, MYC) using a combination of DNA and RNA sequencing. Additionally, the team observed a potentially interesting enrichment of alterations in tumor suppression proteins \u2013 P53 and MLL2 \u2013 in aggressive disease, with cohort expansion and more detailed genotype\/phenotype correlative analysis ongoing.\nOverall, the study demonstrated technical feasibility of comprehensive genomic profiling of DLBCL from archived materials \u2013 formalin-fixed and paraffin-embedded (FFPE) tissue specimens, and provides new understanding of the complexity of the genomic landscape that can be identified through high-resolution technologies.\n\u201cThis research, along with other recent findings, illustrates the daunting molecular diversity of large B-cell lymphoma,\u201d said Andre Goy, M.D. \u201cOur ability to better understand the differences among genomic profiles of lymphoma patients is changing the future practice of oncology; such technology in the hands of oncologists allows them to better determine the best therapy for an individual patient. Precision medicine is here and it is just the beginning of an amazing evolution in patient care!\u201d\nResearchers from John Theurer Cancer Center\u2019s Department of Pathology and Department of Lymphoma, in collaboration with Foundation Medicine, Inc., Cambridge, MA, conducted this research.\nIn this study, an early version of Foundation Medicine\u2019s targeted sequencing assay FoundationOne\u2122 Heme, a fully informative genomic profile for hematologic cancers (leukemia, lymphoma and myeloma), as well as many sarcomas and pediatric cancers, was used to analyze tumor samples. FoundationOne Heme is designed to provide physicians with clinically actionable information to guide treatment options for patients based on the genomic profile of their cancer.\n\u201cThese data demonstrate the potential clinical utility of FoundationOne Heme and represent an important step forward in advancing patient care and enabling precision medicine for patients with large B-cell lymphoma,\u201d said Vincent Miller M.D., Chief Medical Officer of Foundation Medicine.\nAuthors from John Theurer Cancer Center include Dr. Andre Goy, Dr. Andrew L. Pecora, Dr. Anthony R. Mato, Dr. Tatyana Feldman, Dr. Pritish K. Bhattacharyya, Dr. Kar Fai Chow and Ewelina Protomastro.\n\u201cAs one of the premier Lymphoma and Pathology programs in the nation, we are committed to being at the forefront of cutting-edge research and treatment,\u201d said Andrew L. Pecora, M.D., F.A.C.P., C.P.E., Chief Innovations Officer, Professor and Vice President of Cancer Services, John Theurer Cancer Center and President of Regional Cancer Care Associates. \u201cDiscoveries like these highlight the strength of our research team and our commitment to advancing science that holds the promise of new hope for patients.\u201d\nAbout John Theurer Cancer Center at Hackensack University Medical Center\nJohn Theurer Cancer Center at Hackensack University Medical Center is among the nation\u2019s top 50 U.S. News and World Report Best Hospitals for cancer \u2013 the only ranked in New Jersey with this designation. It is New Jersey\u2019s largest and most comprehensive cancer center dedicated to the diagnosis, treatment, management, research, screenings, preventive care, as well as survivorship of patients with all types of cancer.\nEach year, more people in the New Jersey\/New York metropolitan area turn to John Theurer Cancer Center for cancer care than to any other facility in New Jersey. The 14 specialized divisions feature a team of medical, research, nursing, and support staff with specialized expertise that translates into more advanced, focused care for all patients. John Theurer Cancer Center provides comprehensive multidisciplinary care, state of the art technology, access to clinical trials, compassionate care and medical expertise\u2014all under one roof. Physicians at John Theurer Cancer Center are members of Regional Cancer Care Associates one of the nation\u2019s largest professional hematology\/oncology groups. For more information please visit www.jtcancercenter.org.\nAbout Regional Cancer Care Associates\nRegional Cancer Care Associates (RCCA), one of the largest oncology physician networks in the US, is transforming oncology care by ensuring patients and their caregivers are an active part of the treatment team in all aspects of the management of their disease in a way that is life-enriching and respectful.\nRegional Cancer Care Associates extends across New Jersey with more than 90 cancer care specialists, growing to include more than 100, and is supported by 700 employees at 27 care delivery sites, providing care to more than 20,000 new patients annually and over 230,000 existing patients. RCCA takes responsibility to ensure access to the highest quality, compassionate and cutting-edge cancer care for its patients while controlling the cost of this care. For more information visit: www.regionalcancercare.org.\nwe are here for you\nFor more information or to schedule an appointment, call 844-346-7222. You can also schedule an appointment by calling the RCCA location nearest you.\nRELATED ARTICLES\nRegional Cancer Care Associates is one of fewer than 200 medical practices in the country selected to participate in the Oncology Care Model (OCM); a recent Medicare initiative aimed at improving care coordination and access to and quality of care for Medicare beneficiaries undergoing chemotherapy treatment.\n\u00a9 2022 Regional Cancer Care Associates. 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Fight cancer with leading-edge treatments, experienced skill and local caring\/convenience from one of the nation's largest networks of cancer specialists.","email":"info@regionalcancercare.org","mainEntityOfPage":"https:\/\/www.regionalcancercare.org\/","url":"https:\/\/www.regionalcancercare.org\/","sameAs":["https:\/\/twitter.com\/rgnlcancercare","https:\/\/www.facebook.com\/regionalcancercareassoc","https:\/\/www.linkedin.com\/company\/10059183","https:\/\/www.youtube.com\/channel\/UCFlVzU4UvZcyXBCe9ZSvAUQ"],"telephone":"+1 (844) 346-7222","name":"Regional Cancer Care Associates","@id":"https:\/\/www.regionalcancercare.org\/"}],{"@context":"https:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"News","item":"https:\/\/www.regionalcancercare.org\/news\/#breadcrumbitem"},{"@type":"ListItem","position":2,"name":"JTCC Presents Genomic Data on Poor Risk Diffuse Large B-Cell Lymphoma Using Targeted DNA and RNA…","item":"https:\/\/www.regionalcancercare.org\/news\/jtcc-presents-genomic-data-on-poor-risk-diffuse-large-b-cell-lymphoma-using-targeted-dna-and-rna\/#breadcrumbitem"}]}]